The role of sodium retention in Goldblatt 2-kidney hypertension in the rat.
نویسندگان
چکیده
1. Infusion of angiotensin II antagonist failed to restore the blood pressure of short-term Goldblatt 2-kidney hypertensive rats to normal levels before and after sodium restriction. 2. The blood pressure of both normal and sodium-restricted Goldblatt 2 hypertensive rats remained elevated 6 h after bilateral nephrectomy. 3. The residual hypertension found during antagonist infusion and after bilateral nephrectomy is not maintained by the renin-angiotensin system or sodium retention.
منابع مشابه
Influence of sodium restriction upon two models of renal hypertension.
1. Restriction of dietary salt intake does not affect the development or maintenance of hypertension in rats with unilateral renal ischaemia whether the contralateral kidney is present (Goldblatt 2 model) or not (Goldblatt 1 model). 2. Acute dietary salt depletion induces a similar loss of sodium and fall in body weight with little change in blood pressure in both normal and hypertensive rats. ...
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عنوان ژورنال:
- Clinical science and molecular medicine. Supplement
دوره 3 شماره
صفحات -
تاریخ انتشار 1976